Bio-inspired amino acid oxidation by a non-heme iron catalyst modeling the action of 1-aminocyclopropane-1-carboxylic acid oxidase

Chem Commun (Camb). 2010 Oct 21;46(39):7391-3. doi: 10.1039/c0cc01892a. Epub 2010 Sep 7.

Abstract

In this communication we describe the first example of a biomimetic mononuclear iron complex, [Fe(III)(Salen)Cl] (Salen = N,N'-bis(salicylidene)-ethylenediaminato), that highly selectively and efficiently catalyzes the oxidation of 1-aminocyclopropane-1-carboxylic acid (ACCH), α-aminoisobutyric acid (AIBH), and alanine (ALAH) to ethylene or the corresponding carbonyl compounds, mimicking the action of the non-heme iron enzyme 1-aminocyclopropane-1-carboxylic acid oxidase (ACCO).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Oxidoreductases / chemistry*
  • Amino Acids / chemistry*
  • Catalysis
  • Hydrogen Peroxide / chemistry
  • Iron / chemistry*
  • Kinetics
  • Models, Molecular*
  • Oxidation-Reduction
  • Spectrum Analysis / methods

Substances

  • Amino Acids
  • Hydrogen Peroxide
  • Iron
  • Amino Acid Oxidoreductases
  • 1-aminocyclopropane-1-carboxylic acid oxidase