Metabolic control theory: the geometry of the triangle

Biomed Biochim Acta. 1990;49(8-9):801-10.

Abstract

The definitions of flux control coefficients and elasticity coefficients as given in the Metabolic Control Theory are introduced by geometrical considerations. It is shown that a method to determine the (non-normalized) control coefficients from the elasticity coefficients as well as the well-known summation and connectivity relationships can easily be derived in a geometric way. This method is explained in the light of a simple example, but it can be applied to any metabolic system. A software implementation (program "control") and possible applications to biotechnology are briefly presented.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biotechnology
  • Biotransformation
  • Computer Simulation
  • Elasticity
  • Mathematics
  • Metabolism*
  • Models, Biological