Effects of metformin on the reproductive system of androgenized female rats

Roberta Rassi Mahamed; Carla Cristina Maganhin; Ricardo Santos Simões; Manuel de Jesus Simões; Edmund Chada Baracat; José Maria Soares Jr

doi:10.1016/j.fertnstert.2010.07.1093

Effects of metformin on the reproductive system of androgenized female rats

Fertil Steril. 2011 Mar 15;95(4):1507-9. doi: 10.1016/j.fertnstert.2010.07.1093. Epub 2010 Sep 9.

Authors

Roberta Rassi Mahamed¹, Carla Cristina Maganhin, Ricardo Santos Simões, Manuel de Jesus Simões, Edmund Chada Baracat, José Maria Soares Jr

Affiliation

¹ Gynecology Department, Federal University of São Paulo, São Paulo, Brazil.

PMID: 20828684
DOI: 10.1016/j.fertnstert.2010.07.1093

Abstract

Metformin improved the glucose rate and the homeostasis model assessment-insulin resistance (HOMA-IR) index and caused partial reversion of ovaries and uterine morphology in female rats androgenized with testosterone.

Publication types

Comparative Study

MeSH terms

Animals
Female
Insulin Resistance / physiology
Male
Metformin / pharmacology
Metformin / therapeutic use*
Rats
Rats, Wistar
Reproduction / drug effects*
Reproduction / physiology*
Virilism / chemically induced
Virilism / drug therapy*
Virilism / metabolism

Substances

Metformin