Three new stereoisomers of condensed tannins from the roots of Rosa multiflora

Chem Pharm Bull (Tokyo). 2010 Sep;58(9):1227-31. doi: 10.1248/cpb.58.1227.

Abstract

Three new stereoisomers of condensed tannins (1-3), and four known phenolic compounds (4-7) were isolated from the 80% acetone extract of the roots of Rosa multiflora Thunberg. The structures of these compounds were elucidated using 1D/2D NMR, high resolution (HR)-MS, and circular dichroism (CD) spectra. In order to evaluate their anti-oxidative and anti-inflammatory activities, their 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and inhibitory activity on nitric oxide (NO) production were determined.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology*
  • Antioxidants / chemistry*
  • Antioxidants / isolation & purification
  • Antioxidants / pharmacology*
  • Biphenyl Compounds / metabolism
  • Cell Line
  • Cell Survival / drug effects
  • Free Radicals / metabolism
  • Macrophages / cytology
  • Macrophages / drug effects
  • Macrophages / immunology
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Mice
  • Nitric Oxide / immunology
  • Picrates / metabolism
  • Plant Roots / chemistry
  • Proanthocyanidins / chemistry*
  • Proanthocyanidins / isolation & purification
  • Proanthocyanidins / pharmacology*
  • Rosa / chemistry*
  • Stereoisomerism

Substances

  • Anti-Inflammatory Agents
  • Antioxidants
  • Biphenyl Compounds
  • Free Radicals
  • Picrates
  • Proanthocyanidins
  • Nitric Oxide
  • 1,1-diphenyl-2-picrylhydrazyl