Abstract
Three new stereoisomers of condensed tannins (1-3), and four known phenolic compounds (4-7) were isolated from the 80% acetone extract of the roots of Rosa multiflora Thunberg. The structures of these compounds were elucidated using 1D/2D NMR, high resolution (HR)-MS, and circular dichroism (CD) spectra. In order to evaluate their anti-oxidative and anti-inflammatory activities, their 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and inhibitory activity on nitric oxide (NO) production were determined.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemistry*
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology*
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Antioxidants / chemistry*
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Antioxidants / isolation & purification
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Antioxidants / pharmacology*
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Biphenyl Compounds / metabolism
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Cell Line
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Cell Survival / drug effects
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Free Radicals / metabolism
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Macrophages / cytology
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Macrophages / drug effects
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Macrophages / immunology
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Mice
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Nitric Oxide / immunology
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Picrates / metabolism
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Plant Roots / chemistry
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Proanthocyanidins / chemistry*
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Proanthocyanidins / isolation & purification
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Proanthocyanidins / pharmacology*
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Rosa / chemistry*
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Stereoisomerism
Substances
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Anti-Inflammatory Agents
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Antioxidants
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Biphenyl Compounds
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Free Radicals
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Picrates
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Proanthocyanidins
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Nitric Oxide
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1,1-diphenyl-2-picrylhydrazyl