Abstract
Two new drimane sesquiterpenoids, changweikangic acid A (1) and B (2), were isolated from Compound Changweikang. Their structures were established on basis of extensive spectroscopic analyses including two dimensional (2D) NMR and X-ray crystallographic data. The two compounds were evaluated for their inhibitory activity against nitric oxide production in lipopolysaccharide-activated macrophage cell line, RAW 264.7 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemistry*
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology*
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Cell Line
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Crystallography, X-Ray
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Drugs, Chinese Herbal / chemistry*
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Drugs, Chinese Herbal / isolation & purification
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Drugs, Chinese Herbal / pharmacology*
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Ferns / chemistry
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Lipopolysaccharides / immunology
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Macrophages / drug effects
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Macrophages / immunology
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Mice
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Models, Molecular
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Nitric Oxide / antagonists & inhibitors*
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Nitric Oxide / immunology
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Polycyclic Sesquiterpenes
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Polygonum / chemistry
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Sesquiterpenes / chemistry*
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology*
Substances
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Anti-Inflammatory Agents
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Drugs, Chinese Herbal
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Lipopolysaccharides
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Polycyclic Sesquiterpenes
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Sesquiterpenes
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changweikangic acid A
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changweikangic acid B
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drimane
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Nitric Oxide