Two new drimane sesquiterpenoids from compound Changweikang and their inhibitory activity against nitric oxide production

Chem Pharm Bull (Tokyo). 2010 Sep;58(9):1224-6. doi: 10.1248/cpb.58.1224.

Abstract

Two new drimane sesquiterpenoids, changweikangic acid A (1) and B (2), were isolated from Compound Changweikang. Their structures were established on basis of extensive spectroscopic analyses including two dimensional (2D) NMR and X-ray crystallographic data. The two compounds were evaluated for their inhibitory activity against nitric oxide production in lipopolysaccharide-activated macrophage cell line, RAW 264.7 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology*
  • Cell Line
  • Crystallography, X-Ray
  • Drugs, Chinese Herbal / chemistry*
  • Drugs, Chinese Herbal / isolation & purification
  • Drugs, Chinese Herbal / pharmacology*
  • Ferns / chemistry
  • Lipopolysaccharides / immunology
  • Macrophages / drug effects
  • Macrophages / immunology
  • Mice
  • Models, Molecular
  • Nitric Oxide / antagonists & inhibitors*
  • Nitric Oxide / immunology
  • Polycyclic Sesquiterpenes
  • Polygonum / chemistry
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology*

Substances

  • Anti-Inflammatory Agents
  • Drugs, Chinese Herbal
  • Lipopolysaccharides
  • Polycyclic Sesquiterpenes
  • Sesquiterpenes
  • changweikangic acid A
  • changweikangic acid B
  • drimane
  • Nitric Oxide