The current scientific and legal status of alternative methods to the LD50 test for botulinum neurotoxin potency testing. The report and recommendations of a ZEBET Expert Meeting

Altern Lab Anim. 2010 Aug;38(4):315-30. doi: 10.1177/026119291003800401.
No abstract available

MeSH terms

  • Acetylcholine / antagonists & inhibitors
  • Animal Testing Alternatives / legislation & jurisprudence
  • Animal Testing Alternatives / methods*
  • Animals
  • Botulinum Toxins / toxicity*
  • Diaphragm / drug effects
  • Diaphragm / physiology
  • Europe
  • Lethal Dose 50
  • Mice
  • Nerve Endings / drug effects
  • Nerve Endings / physiology
  • Neuromuscular Junction / drug effects
  • Neuromuscular Junction / physiology*
  • Reproducibility of Results

Substances

  • Botulinum Toxins
  • Acetylcholine