Stereodivergent construction of aminodiols with a CF3 group

Org Lett. 2010 Oct 1;12(19):4316-9. doi: 10.1021/ol101459a.

Authors

Ryusuke Obinata¹, Tomoko Kawasaki-Takasuka, Takashi Yamazaki

Affiliation

¹ Division of Applied Chemistry, Institute of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei 184-8588, Japan.

PMID: 20822155
DOI: 10.1021/ol101459a

Abstract

A stereodivergent synthesis of various 2-amino-1,3-diols and 3-amino-1,2-diols from a single intermediate, 2,3-epoxyketones, is described.