Acute toxicity of emamectin benzoate and its desmethyl metabolite to Eohaustorius estuarius

Environ Toxicol Chem. 2010 Aug;29(8):1816-20. doi: 10.1002/etc.209.

Abstract

Emamectin benzoate is one of the active ingredients of the anti-sealice drug SLICE. Ten-day acute sediment lethal tests (10-d LC50) of emamectin benzoate and its desmethyl metabolite (AB1) were conducted to determine LC50 values using a sensitive representative West Coast amphipod crustacean, Eohaustorius estuarius. The 10-d LC50s of emamectin benzoate and AB1 to E. estuarius were 0.185 and 0.019 mg/kg wet weight sediment (0.146 and 0.015 mg/kg dry wt), respectively. The degradation properties of emamectin benzoate and AB1 during the 10-d period were also measured and described. No obvious decay patterns were observed for either emamectin benzoate and AB1 over the 10-d period.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphipoda / drug effects*
  • Animals
  • Antiparasitic Agents / analysis
  • Antiparasitic Agents / toxicity*
  • Dose-Response Relationship, Drug
  • Geologic Sediments / chemistry
  • Ivermectin / analogs & derivatives*
  • Ivermectin / analysis
  • Ivermectin / toxicity
  • Toxicity Tests, Acute
  • Water Pollutants, Chemical / analysis
  • Water Pollutants, Chemical / toxicity

Substances

  • 4'-amino-4'-avermectin B1 benzoate
  • Antiparasitic Agents
  • Water Pollutants, Chemical
  • Ivermectin
  • emamectin benzoate