Abstract
Multiplexed SERS imaging of receptor proteins on the surface of mammalian cells has been carried out using functionalized silver nanoparticles. Deconvolution of four differently functionalized nanoparticles is readily achieved, and using this approach, receptor co-localization can be probed and protein-protein interactions can be elucidated at the surface of cells.
MeSH terms
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Animals
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Caveolin 3 / chemistry
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Ligands
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Membrane Proteins / chemistry*
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Metal Nanoparticles / chemistry*
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Metal Nanoparticles / ultrastructure
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Microscopy, Confocal
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Myocytes, Cardiac / cytology
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Rats
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Receptors, Adrenergic, beta-2 / chemistry
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Silver / chemistry
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Spectrum Analysis, Raman
Substances
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Caveolin 3
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Ligands
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Membrane Proteins
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Receptors, Adrenergic, beta-2
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Silver