A fragment-based in situ combinatorial approach to identify high-affinity ligands for unknown binding sites

Angew Chem Int Ed Engl. 2010 Aug 2;49(33):5721-5. doi: 10.1002/anie.200907254.

Authors

Sachin V Shelke¹, Brian Cutting, Xiaohua Jiang, Hendrik Koliwer-Brandl, Daniel S Strasser, Oliver Schwardt, Soerge Kelm, Beat Ernst

Affiliation

¹ Institute of Molecular Pharmacy, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.

PMID: 20818756
DOI: 10.1002/anie.200907254

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Binding Sites
Combinatorial Chemistry Techniques*
Drug Evaluation, Preclinical
Ligands*
Magnetic Resonance Spectroscopy
Myelin-Associated Glycoprotein / chemistry

Substances

Ligands
Myelin-Associated Glycoprotein