The first Irish genome and ways of improving sequence accuracy

Genome Biol. 2010;11(9):132. doi: 10.1186/gb-2010-11-9-132. Epub 2010 Sep 7.

Abstract

Whole-genome sequencing of an Irish person reveals hundreds of thousands of novel genomic variants. Imputation using previous known information improves the accuracy of low-read-depth sequencing.

Publication types

  • Comment

MeSH terms

  • Base Sequence
  • Chromosome Mapping
  • Genome, Human*
  • Genomics
  • Hepatocyte Growth Factor / genetics
  • Humans
  • Ireland
  • Mutation
  • Polymorphism, Single Nucleotide*
  • Proto-Oncogene Proteins / genetics
  • Sequence Analysis, DNA*

Substances

  • Proto-Oncogene Proteins
  • macrophage stimulating protein
  • Hepatocyte Growth Factor