Abstract
Small oligomers of constrained dipeptide mimics have been synthesized as new vectors for intracellular delivery. They are highly internalized by cells and delivered to the lysosomes by an energy-dependent pathway. This new class of vectors referred to as cell penetrating nonpeptides (CPNP) possess the distinctive feature of being noncationic.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Biological Transport
-
Cell Line, Tumor
-
Dipeptides / chemistry*
-
Humans
-
Intracellular Space / metabolism
-
Peptidomimetics / chemistry*
-
Peptidomimetics / metabolism*
-
Polymers / chemistry
-
Polymers / metabolism
-
Thiazepines / chemistry
Substances
-
Dipeptides
-
Peptidomimetics
-
Polymers
-
Thiazepines