Braak staging in mouse models of Alzheimer's disease

Am J Pathol. 2010 Oct;177(4):1603-5. doi: 10.2353/ajpath.2010.100656. Epub 2010 Sep 2.

Abstract

In the present paper by David E. Hurtado and colleagues report on a new mouse model for AD bearing Aβ and MAPT pathology by crossing PS19 and PDAPP Tg mice. Here, we tried to highlight the importance and necessity of the critical and systematic analysis of models such as the Braak like staging in AD mouse models.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / metabolism
  • Alzheimer Disease / pathology*
  • Amyloid beta-Peptides / genetics
  • Amyloid beta-Peptides / metabolism*
  • Amyloidosis / etiology*
  • Amyloidosis / metabolism
  • Amyloidosis / pathology
  • Animals
  • Crosses, Genetic
  • Disease Models, Animal*
  • Humans
  • Mice
  • Mice, Transgenic
  • Neurofibrillary Tangles / metabolism
  • Neurofibrillary Tangles / pathology*
  • tau Proteins / metabolism*

Substances

  • Amyloid beta-Peptides
  • tau Proteins