Abstract
Several N,O-nucleosides have been synthesized in good yields by direct 1,3-dipolar cyclization methodology, in the absence of solvent. A remarkable cis stereoselectivity (de 98%) was observed by tuning the substituents on the nitrone moiety. A good number of these N,O-nucleosides have been evaluated for cytotoxic activity against selected cellular lines. Some of the tested compounds have proven to be potential antiproliferative drugs.
Copyright © 2010 Elsevier Ltd. All rights reserved.
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Apoptosis / drug effects
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B-Lymphocytes / drug effects
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Cell Line
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Cell Proliferation / drug effects
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Cyclization
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Drug Screening Assays, Antitumor
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Humans
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Jurkat Cells / drug effects
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Molecular Structure
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Nucleosides / chemical synthesis
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Nucleosides / chemistry*
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Nucleosides / pharmacology*
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Nucleosides