Abstract
Dihydro-resveratrol (dihydro-R), a prominent polyphenol component of red wine, has a profound proliferative effect on hormone-sensitive tumor cell lines such as breast cancer cell line MCF7. We found a significant increase in MCF7 tumor cells growth rates in the presence of picomolar concentrations of this compound. The proliferative effect of dihydro-R was not observed in cell lines that do not express hormone receptors (MDA-MB-231, BT-474, and К-562).
Copyright © 2010 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Breast Neoplasms / drug therapy
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Cell Line, Tumor
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Cell Proliferation / drug effects*
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Dietary Supplements
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Female
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Flavonoids / chemistry
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Flavonoids / pharmacology
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Humans
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Neoplasms, Hormone-Dependent / drug therapy
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Phenols / chemistry
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Phenols / pharmacology
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Polyphenols
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Resveratrol
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Stilbenes / chemistry*
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Stilbenes / pharmacology*
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Wine
Substances
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Antineoplastic Agents, Phytogenic
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Flavonoids
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Phenols
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Polyphenols
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Stilbenes
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Resveratrol