Epithelium-derived linoleic acid metabolites modulate airway smooth muscle function

Agents Actions Suppl. 1990:31:283-6. doi: 10.1007/978-3-0348-7379-6_39.

Abstract

Cultured epithelial cells obtained from guinea pig tracheal preparations metabolized arachidonic acid into 5- and 15-hydroxy-eicosatetraenoic acid and into the prostaglandins E2 and F2 alpha. Linoleic acid was converted by the epithelial cells into 9-hydroxy-octadecadienoic acid (9-HODE) and smaller amounts of 13-HODE. It was further investigated whether linoleic acid metabolites are of importance for the regulation of airway smooth muscle function. 13-HODE caused an increase of maximal contraction of tracheal rings to histamine, while 9-HODE had no effect.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Epithelial Cells
  • Epithelium / metabolism
  • Epithelium / physiology
  • Histamine / pharmacology
  • Linoleic Acid
  • Linoleic Acids / metabolism*
  • Linoleic Acids / pharmacology
  • Linoleic Acids, Conjugated*
  • Muscle Contraction / drug effects
  • Muscle, Smooth / cytology
  • Muscle, Smooth / metabolism
  • Muscle, Smooth / physiology*
  • Trachea / cytology
  • Trachea / metabolism
  • Trachea / physiology*

Substances

  • Linoleic Acids
  • Linoleic Acids, Conjugated
  • 9-hydroxy-10,12-octadecadienoic acid
  • 13-hydroxy-9,11-octadecadienoic acid
  • Histamine
  • Linoleic Acid