Abstract
In this study, we examined the effects of IL-18 deficiency on behaviors and gene expression profiles in 6 brain regions. IL-18(-/-) mice reduced depressive-like behavior and changed gene expressions predominantly in the amygdala compared with wild-type mice. Pathway analysis of the differentially expressed genes ranked behavior as the top-scored biological function. Of note, the absence of IL-18 decreased Avp, Hcrt, Oxt, and Pmch mRNA levels and the number of arginine vasopressin- and oxytocin-positive cells in the amygdala, but not in the hypothalamus. Our results suggest that IL-18-dependent vasopressinergic and oxytocinergic circuitry in the amygdala may regulate depressive-like behaviors in mice.
Copyright © 2010 Elsevier B.V. All rights reserved.
MeSH terms
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Adaptation, Physiological / genetics
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Agouti Signaling Protein / genetics
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Agouti Signaling Protein / metabolism
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Amygdala / metabolism*
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Analysis of Variance
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Animals
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Behavior, Animal
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Computational Biology / methods
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Exploratory Behavior / physiology
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Gene Expression Profiling / methods
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Gene Expression Regulation / genetics*
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Hypothalamic Hormones / genetics
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Hypothalamic Hormones / metabolism
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Interleukin-18 / deficiency*
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Intracellular Signaling Peptides and Proteins / genetics
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Intracellular Signaling Peptides and Proteins / metabolism
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Male
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Maze Learning / physiology
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Neuropeptides / genetics
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Neuropeptides / metabolism*
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Oligonucleotide Array Sequence Analysis / methods
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Orexins
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Oxytocin / genetics
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Oxytocin / metabolism
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Protein Precursors / genetics
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Protein Precursors / metabolism
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Swimming / psychology
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Vasopressins / genetics
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Vasopressins / metabolism
Substances
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Agouti Signaling Protein
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Hypothalamic Hormones
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Interleukin-18
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Intracellular Signaling Peptides and Proteins
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Neuropeptides
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Orexins
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Protein Precursors
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a protein, mouse
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Vasopressins
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melanin-concentrating hormone precursors
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Oxytocin