Synthesis of the pentasaccharide repeating unit of Escherichia coli O128 antigen

Xun Lv; Shuihong Cheng; Guoha Wei; Yuguo Du

doi:10.1016/j.carres.2010.07.025

Synthesis of the pentasaccharide repeating unit of Escherichia coli O128 antigen

Carbohydr Res. 2010 Oct 13;345(15):2272-6. doi: 10.1016/j.carres.2010.07.025. Epub 2010 Jul 21.

Authors

Xun Lv¹, Shuihong Cheng, Guoha Wei, Yuguo Du

Affiliation

¹ State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

PMID: 20804976
DOI: 10.1016/j.carres.2010.07.025

Abstract

A pentasaccharide, 4-methoxyphenyl 2-acetamido-2-deoxy-β-d-galactopyranosyl-(1→4)-α-d-galactopyranosyl-(1→3)-2-acetamido-2-deoxy-β-d-galactopyranosyl-(1→6)-[α-l-fucopyranosyl-(1→2)]-β-d-galactopyranoside (1), representing the repeating unit of Escherichia coli O128 antigen, was successfully prepared in 23% overall yield via a convergent '2+3' glycosylation strategy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbohydrate Sequence
Escherichia coli / chemistry*
Glycosylation
Molecular Sequence Data
Molecular Structure
O Antigens / chemistry*
Oligosaccharides / chemical synthesis*
Oligosaccharides / chemistry*

Substances

O Antigens
Oligosaccharides