Abstract
Two new 5-O-glucosylflavones, 5-O-β-D-glucopyranosyl cirsimaritin (1) and 5, 4'-O-β-D-diglucopyranosyl cirsimaritin (2), four known flavonoids, cirsimarin (3), cirsimaritin (4), salvigenin (5), 4', 5-dihydroxy-7-methoxyflavone (6), and a norisoprenoid, vomifoliol (7), have been isolated from the aerial parts of Microtea debilis. All isolates were tested for cytotoxicity in human cancer cell lines (Hep G2, COLO 205, and HL-60) and anti-inflammatory activities in LPS-treated RAW264.7 macrophages. Compound 6 was found to be a potent inhibitor to nitrite production in macrophages. Compounds 2, 4, 6, and 7 showed moderate anti-proliferative activity against COLO-205 cells with IC(50) values of 7.1, 13.1, 6.1, and 6.8 μM, respectively.
Copyright © 2010 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology*
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Anti-Inflammatory Agents / therapeutic use
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Antineoplastic Agents, Phytogenic / therapeutic use
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Flavones / isolation & purification
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Flavones / pharmacology*
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Flavones / therapeutic use
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Glucosides / isolation & purification
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Glucosides / pharmacology*
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Glucosides / therapeutic use
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Hep G2 Cells
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Humans
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Lipopolysaccharides
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Macrophages / drug effects
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Macrophages / metabolism
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Mice
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Neoplasms / drug therapy
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Nitrites / metabolism
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Phytolaccaceae / chemistry*
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Phytotherapy*
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Plant Components, Aerial
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
Substances
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5,4'-O-beta-D-diglucopyranosyl cirsimaritin
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5-O-beta-D-glucopyranosyl cirsimaritin
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Anti-Inflammatory Agents
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Antineoplastic Agents, Phytogenic
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Flavones
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Glucosides
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Lipopolysaccharides
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Nitrites
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Plant Extracts