One-pot desulfurative-fluorination-bromination. Synthesis of 2,5-dibromo-3-(1,1-difluoroalkyl)thiophenes

Nashaat Turkman; Lingling An; Martin Pomerantz

doi:10.1021/ol101907k

One-pot desulfurative-fluorination-bromination. Synthesis of 2,5-dibromo-3-(1,1-difluoroalkyl)thiophenes

Org Lett. 2010 Oct 1;12(19):4428-30. doi: 10.1021/ol101907k.

Authors

Nashaat Turkman¹, Lingling An, Martin Pomerantz

Affiliation

¹ Department of Chemistry and Biochemistry, Box 19065, The University of Texas at Arlington, Arlington, Texas 76019-0065, USA.

PMID: 20804150
DOI: 10.1021/ol101907k

Abstract

A unique one-pot, high-yield desulfurative-fluorination-bromination reaction which leads to the synthesis of 2,5-dibromo-3-(1,1-difluoroalkyl)thiophenes is reported. A single dithiolane reactant can be used to produce both 2,5-dibromo-3-(1,1-difluoroalkyl)thiophene and 3-(1,1-difluoroalkyl)thiophene with longer alkyl chains.