Pd-catalyzed oxidative cross-coupling of perfluoroarenes with aromatic heterocycles

Chun-Yang He; Shilu Fan; Xingang Zhang

doi:10.1021/ja106046p

Pd-catalyzed oxidative cross-coupling of perfluoroarenes with aromatic heterocycles

J Am Chem Soc. 2010 Sep 22;132(37):12850-2. doi: 10.1021/ja106046p.

Authors

Chun-Yang He¹, Shilu Fan, Xingang Zhang

Affiliation

¹ Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.

PMID: 20804140
DOI: 10.1021/ja106046p

Abstract

A straightforward and practical method for direct Pd(OAc)(2)-catalyzed oxidative cross-coupling of electron-deficient perfluoroarenes with aromatic heterocycles has been developed. Because of its low catalyst loading (2.5 mol %), high reaction efficiency, good chemo- and regioselectivity, and excellent functional-group compatibility, this protocol provides a useful and operationally simple access to perfluoroarene-thiophene structures of interest in functional materials for electronic devices.