A highly sensitive and selective turn-on fluorogenic and chromogenic sensor based on BODIPY-functionalized magnetic nanoparticles for detecting lead in living cells

Hyunjong Son; Hye Young Lee; Jung Mi Lim; Dongmin Kang; Won Seok Han; Shim Sung Lee; Jong Hwa Jung

doi:10.1002/chem.201001772

A highly sensitive and selective turn-on fluorogenic and chromogenic sensor based on BODIPY-functionalized magnetic nanoparticles for detecting lead in living cells

Chemistry. 2010 Oct 11;16(38):11549-53. doi: 10.1002/chem.201001772. Epub 2010 Aug 27.

Authors

Hyunjong Son¹, Hye Young Lee, Jung Mi Lim, Dongmin Kang, Won Seok Han, Shim Sung Lee, Jong Hwa Jung

Affiliation

¹ Department of Chemistry and Research Institute of Natural Sciences, Gyeongsang National University, Jinju 660-701, Korea.

PMID: 20803587
DOI: 10.1002/chem.201001772

Abstract

A new fluoro-chromogenic chemosensor based on BODIPY-functionalized Fe(3)O(4)@SiO(2) core/shell nanoparticles 1 has been prepared. Chemosensor 1 exhibits a high affinity and selectivity for Pb(2+) over competing metal ions tested. Moreover, confocal microscopy, and flow cytometry experiments established that 1 can be used for detecting Pb(2+) levels within living cell.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Boron Compounds / chemistry*
Ferrosoferric Oxide / chemistry
Flow Cytometry
HeLa Cells
Humans
Ions / chemistry
Lead / analysis*
Magnetics
Microscopy, Fluorescence*
Nanoparticles / chemistry*
Silicon Dioxide / chemistry

Substances

4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
Boron Compounds
Ions
Lead
Silicon Dioxide
Ferrosoferric Oxide