Macrocycles as a tool: a facile and one-pot synthesis of silver nanoparticles using cucurbituril designed for cancer therapeutics

Chemistry. 2010 Oct 11;16(38):11563-6. doi: 10.1002/chem.201001325. Epub 2010 Aug 27.

Abstract

Silver nanoparticles made easy: A simple, effective, and one-pot method toward the synthesis of a defined macrocycle-silver nanoparticle system in water has been described (see figure). Interestingly, cucurbituril (CB)[7]-protected AgNPs showed significantly increased cytotoxicity against MCF-7 and NCI-H358 cancer cells, as demonstrated by models in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bridged-Ring Compounds / chemistry*
  • Bridged-Ring Compounds / therapeutic use
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Humans
  • Imidazoles / chemistry*
  • Imidazoles / therapeutic use
  • MCF-7 Cells
  • Metal Nanoparticles / chemistry*
  • Metal Nanoparticles / toxicity
  • Neoplasms / drug therapy
  • Particle Size
  • Silver / chemistry*
  • Sodium Hydroxide / chemistry
  • Water / chemistry

Substances

  • Bridged-Ring Compounds
  • Imidazoles
  • cucurbit(7)uril
  • Water
  • Silver
  • Sodium Hydroxide