SEPT12 deficiency causes sperm nucleus damage and developmental arrest of preimplantation embryos

Fertil Steril. 2011 Jan;95(1):363-5. doi: 10.1016/j.fertnstert.2010.07.1064.

Abstract

Oocytes fertilized with spermatozoa obtained from Septin 12+/- chimeric mice failed to develop beyond the morula stage after IVF and intracytoplasmic sperm injection because of significant DNA defects in the spermatozoa. Given that SEPT12 is expressed at the edge of the sperm nucleus in both humans and mice, we hypothesized the vital roles of Septin 12 in sperm head shaping, nuclear DNA condensation, and early embryonic development.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Nucleus / pathology
  • Cell Nucleus / physiology
  • Embryonic Development / physiology*
  • Female
  • Infertility, Male / genetics*
  • Infertility, Male / pathology*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Mutant Strains
  • Morula / pathology
  • Pregnancy
  • Septins / deficiency
  • Septins / genetics*
  • Sperm Head / pathology*
  • Sperm Head / physiology
  • Sperm Injections, Intracytoplasmic

Substances

  • SEPT12 protein, mouse
  • Septins