Termination at sTop2

Robert C Alver; Anja-Katrin Bielinsky

doi:10.1016/j.molcel.2010.08.006

Termination at sTop2

Mol Cell. 2010 Aug 27;39(4):487-9. doi: 10.1016/j.molcel.2010.08.006.

Authors

Robert C Alver¹, Anja-Katrin Bielinsky

Affiliation

¹ Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.

Abstract

In this issue of Molecular Cell, Fachinetti et al. provide the first comprehensive map of replication termination sites (TERs) in Saccharomyces cerevisiae (Fachinetti et al., 2010). Strikingly, the majority of TERs are occupied by topoisomerase 2, which shields these regions against genomic instability.

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