The effect of 5-fluorouracil on inhibition of epidermal DNA synthesis in vivo: a comparison of the effect of formulations and a prodrug of 5-FU

Arch Dermatol Res. 1990;282(7):484-6. doi: 10.1007/BF00402629.

Authors

K B Sloan¹, E F Sherertz, R G McTiernan

Affiliation

¹ University of Florida, Department of Medicinal Chemistry, Gainesville 32610.

PMID: 2078053
DOI: 10.1007/BF00402629

No abstract available

Publication types

Comparative Study
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Administration, Cutaneous
Animals
DNA / analysis
DNA / biosynthesis*
DNA / drug effects
Deoxyuridine / metabolism
Dose-Response Relationship, Drug
Epidermis / chemistry
Epidermis / drug effects
Epidermis / metabolism*
Female
Fluorouracil / administration & dosage
Fluorouracil / pharmacology*
Mice
Mice, Nude
Prodrugs / pharmacology

Substances

Prodrugs
DNA
Fluorouracil
Deoxyuridine