Resulting from the experimental investigations on 70 dogs and analysis of 3 clinical cases, the authors have established that cryodestruction of the pancreas in extensive hemorrhagic pancreonecrosis permitted to cup off promptly the enzymatic toxemia and prevented the development of secondary purulent complications. The most pronounced anti-enzyme effect was noted in combination of the corpus-caudal resection of the pancreas and cryodestruction of the organ remainder.