Communicating pharmacogenetic research results to breastfeeding mothers taking codeine: a pilot study of perceptions and benefits

Clin Pharmacol Ther. 2010 Dec;88(6):792-5. doi: 10.1038/clpt.2010.125. Epub 2010 Aug 25.

Abstract

Sixty-two codeine-prescribed breastfeeding mothers from a pharmacogenetic study were interviewed regarding the communication of individual CYP2D6 genotype results and overall research findings. All participants wanted to receive the results of their individual genetic tests; however, individuals placed different values on the usefulness of this information toward future medical decisions. Receiving one's pharmacogenetic test results was not associated with a negative psychosocial impact. Thirty-three percent of the participants wished to withhold these results from their physicians. Participants' expectations seem to dictate the extent of transparency of pharmacogenetic research results.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Breast Feeding* / adverse effects
  • Breast Feeding* / psychology
  • Codeine / adverse effects*
  • Codeine / metabolism
  • Cohort Studies
  • Communication*
  • Cytochrome P-450 CYP2D6 / genetics
  • Female
  • Genetic Testing / methods
  • Genetic Testing / psychology
  • Humans
  • Infant, Newborn
  • Patient Preference / psychology
  • Perception*
  • Pharmacogenetics / methods*
  • Pharmacogenetics / trends
  • Pilot Projects
  • Professional-Patient Relations*
  • Surveys and Questionnaires

Substances

  • Cytochrome P-450 CYP2D6
  • Codeine