Cancer-preventive activities of secondary metabolites from leaves of the bilberry Vaccinium smallii A. Gray

G Ya Mechikova; A S Kuzmich; L P Ponomarenko; A I Kalinovsky; T A Stepanova; S N Fedorov; V A Stonik

doi:10.1002/ptr.3282

Cancer-preventive activities of secondary metabolites from leaves of the bilberry Vaccinium smallii A. Gray

Phytother Res. 2010 Nov;24(11):1730-2. doi: 10.1002/ptr.3282.

Authors

G Ya Mechikova¹, A S Kuzmich, L P Ponomarenko, A I Kalinovsky, T A Stepanova, S N Fedorov, V A Stonik

Affiliation

¹ Far-Eastern State Medical University, Murav'eva-Amurskogo st. 35, Khabarovsk, 680000, Russian Federation.

PMID: 20737623
DOI: 10.1002/ptr.3282

Abstract

Ten secondary metabolites including flavonoids (1-8), caffeic (9) and chlorogenic (10) acids were structurally identified from the extract of Sakhalin bilberry Vaccinium smallii leaves and studied in vitro as potential cancer-preventive agents. The results showed that compounds 1-10 inhibited EGF-induced neoplastic transformation of mouse JB6 Cl 41 P+ cells in soft agar with an inhibition concentration (INCC50) of 20-80 µm. Moreover, all these natural products were non-toxic against JB6 Cl 41 P+ cells up to a concentration of 200 µm.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacokinetics*
Caffeic Acids / isolation & purification
Caffeic Acids / pharmacology
Cell Line, Tumor
Chlorogenic Acid / isolation & purification
Chlorogenic Acid / pharmacology
Flavonoids / isolation & purification
Flavonoids / pharmacology*
HeLa Cells
Humans
Mice
Molecular Structure
Plant Extracts / pharmacology*
Plant Leaves / chemistry
Vaccinium myrtillus / chemistry*

Substances

Antineoplastic Agents, Phytogenic
Caffeic Acids
Flavonoids
Plant Extracts
Chlorogenic Acid
caffeic acid