Abstract
Frequency of extensively drug-resistant tuberculosis in Pakistan increased from 1.5% in 2006 to 4.5% in 2009 (p<0.01). To understand the epidemiology, we genotyped selected strains by using spoligotyping, mycobacterial interspersed repetitive units-variable number of tandem repeats, and IS6110 restriction fragment length polymorphism analysis.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Base Sequence
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DNA Primers / genetics
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DNA Transposable Elements
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DNA, Bacterial / genetics
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DNA, Bacterial / isolation & purification
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Drug Resistance, Multiple, Bacterial / genetics
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Extensively Drug-Resistant Tuberculosis / epidemiology*
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Extensively Drug-Resistant Tuberculosis / microbiology*
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Female
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Genotype
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Humans
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Interspersed Repetitive Sequences
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Male
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Middle Aged
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Minisatellite Repeats
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Molecular Epidemiology
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Mycobacterium tuberculosis / classification
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Mycobacterium tuberculosis / drug effects
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Mycobacterium tuberculosis / genetics*
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Mycobacterium tuberculosis / isolation & purification
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Pakistan / epidemiology
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Polymorphism, Restriction Fragment Length
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Young Adult
Substances
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DNA Primers
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DNA Transposable Elements
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DNA, Bacterial