Extensively drug-resistant tuberculosis, Pakistan

Emerg Infect Dis. 2010 Sep;16(9):1473-5. doi: 10.3201/eid1609.100280.

Abstract

Frequency of extensively drug-resistant tuberculosis in Pakistan increased from 1.5% in 2006 to 4.5% in 2009 (p<0.01). To understand the epidemiology, we genotyped selected strains by using spoligotyping, mycobacterial interspersed repetitive units-variable number of tandem repeats, and IS6110 restriction fragment length polymorphism analysis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Base Sequence
  • DNA Primers / genetics
  • DNA Transposable Elements
  • DNA, Bacterial / genetics
  • DNA, Bacterial / isolation & purification
  • Drug Resistance, Multiple, Bacterial / genetics
  • Extensively Drug-Resistant Tuberculosis / epidemiology*
  • Extensively Drug-Resistant Tuberculosis / microbiology*
  • Female
  • Genotype
  • Humans
  • Interspersed Repetitive Sequences
  • Male
  • Middle Aged
  • Minisatellite Repeats
  • Molecular Epidemiology
  • Mycobacterium tuberculosis / classification
  • Mycobacterium tuberculosis / drug effects
  • Mycobacterium tuberculosis / genetics*
  • Mycobacterium tuberculosis / isolation & purification
  • Pakistan / epidemiology
  • Polymorphism, Restriction Fragment Length
  • Young Adult

Substances

  • DNA Primers
  • DNA Transposable Elements
  • DNA, Bacterial