Resveratrol oligomers from Vatica albiramis

J Nat Prod. 2010 Sep 24;73(9):1499-506. doi: 10.1021/np1002675.

Abstract

Five new stilbenoids, vatalbinosides A-E (1-5), and 13 known compounds (6-18) were isolated from the stem of Vatica albiramis. The effects of these new compounds on interleukin-1β-induced production of matrix metalloproteinase-1 (MMP-1) in human dermal fibroblasts were examined. Three resveratrol tetramers, (-)-hopeaphenol (6), vaticanol C (13), and stenophyllol C (14), were identified as strong inhibitors of MMP-1 production.

MeSH terms

  • Dipterocarpaceae / chemistry*
  • Fibroblasts / drug effects
  • Humans
  • Interleukin-1beta / drug effects*
  • Malaysia
  • Matrix Metalloproteinase 1 / biosynthesis*
  • Matrix Metalloproteinase 1 / drug effects
  • Molecular Structure
  • Phenols
  • Plant Stems / chemistry
  • Plants, Medicinal / chemistry*
  • Resveratrol
  • Skin / cytology
  • Skin / drug effects
  • Stereoisomerism
  • Stilbenes / chemistry*
  • Stilbenes / isolation & purification*
  • Stilbenes / pharmacology

Substances

  • Interleukin-1beta
  • Phenols
  • Stilbenes
  • hopeaphenol
  • vaticanol C
  • Matrix Metalloproteinase 1
  • Resveratrol