Abstract
Five new stilbenoids, vatalbinosides A-E (1-5), and 13 known compounds (6-18) were isolated from the stem of Vatica albiramis. The effects of these new compounds on interleukin-1β-induced production of matrix metalloproteinase-1 (MMP-1) in human dermal fibroblasts were examined. Three resveratrol tetramers, (-)-hopeaphenol (6), vaticanol C (13), and stenophyllol C (14), were identified as strong inhibitors of MMP-1 production.
MeSH terms
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Dipterocarpaceae / chemistry*
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Fibroblasts / drug effects
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Humans
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Interleukin-1beta / drug effects*
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Malaysia
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Matrix Metalloproteinase 1 / biosynthesis*
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Matrix Metalloproteinase 1 / drug effects
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Molecular Structure
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Phenols
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Plant Stems / chemistry
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Plants, Medicinal / chemistry*
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Resveratrol
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Skin / cytology
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Skin / drug effects
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Stereoisomerism
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Stilbenes / chemistry*
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Stilbenes / isolation & purification*
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Stilbenes / pharmacology
Substances
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Interleukin-1beta
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Phenols
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Stilbenes
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hopeaphenol
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vaticanol C
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Matrix Metalloproteinase 1
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Resveratrol