The paper considers the specific features of the psychoemotional sphere and the properties of the nervous system, and psychophysiological reactions in teachers dwelling in different areas of the Far North-East of Russia. It has been established that the Magadan Region's teachers show a high psychoemotional tension, weakness, inertness, and instability of nervous processes. Asthenization, anxiety, and neurotic states along with decreased central nervous system performance were more pronounced in teachers living in the remote settlement of Evensk when natural, climatic, and social conditions become more severe.