Reactions of medicinally relevant gold compounds with the C-terminal motif of thioredoxin reductase elucidated by MS analysis

Chem Commun (Camb). 2010 Oct 7;46(37):7001-3. doi: 10.1039/c0cc01465f. Epub 2010 Aug 23.

Abstract

The tetrapeptide Ac-Gly-[Cys-Sec]-Gly-NH(2), reproducing the C-terminal motif of the selenoenzyme thioredoxin reductase, was designed and synthesized, and its reactions with a few medicinally relevant gold(i,iii) compounds investigated by ESI-MS. Remarkably, the main reaction products could be unambiguously identified providing valuable insight into the likely mechanisms of enzyme inhibition by gold compounds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Gold Compounds / chemistry*
  • Models, Molecular
  • Molecular Structure
  • Oligopeptides / chemical synthesis*
  • Oligopeptides / chemistry
  • Spectrometry, Mass, Electrospray Ionization
  • Thioredoxin-Disulfide Reductase / chemistry
  • Thioredoxin-Disulfide Reductase / metabolism*

Substances

  • Gold Compounds
  • Oligopeptides
  • Thioredoxin-Disulfide Reductase