Abstract
We investigated the activity of tigecycline in combination with gentamicin for the treatment of biofilm-forming methicillin-resistant and sensitive Staphylococcus aureus in an in vitro pharmacodynamic model. Tigecycline monotherapy demonstrated bacteriostatic activity throughout 48 h (-0.24 +/- 0.17 log(10) CFU/mL), whereas tigecycline in combination with gentamicin demonstrated significant (P < 0.002) kill (-3.66 +/- 0.26 log(10) CFU/mL) at 48 h. The addition of gentamicin to tigecycline significantly improved the killing activity of tigecycline in biofilm-forming S. aureus.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Biofilms / drug effects*
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Biofilms / growth & development
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Culture Media
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Drug Interactions
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Drug Therapy, Combination
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Gentamicins / pharmacology*
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Humans
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Methicillin-Resistant Staphylococcus aureus / drug effects*
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Methicillin-Resistant Staphylococcus aureus / physiology
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Microbial Sensitivity Tests
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Minocycline / analogs & derivatives*
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Minocycline / pharmacology
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Models, Biological
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Staphylococcal Infections / microbiology
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / physiology
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Tigecycline
Substances
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Anti-Bacterial Agents
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Culture Media
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Gentamicins
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Tigecycline
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Minocycline