Restriction of rear-up-behavior-induced attenuation of vestibulo-cardiovascular reflex in rats

Abstract

Previously, we have demonstrated that the vestibulo-cardiovascular reflex was attenuated in rats reared in a 3G environment for 14 days. Because continuous galvanic vestibular stimulation preserved the vestibulo-cardiovascular reflex in rats at 3G, this attenuation might be attributable to a reduction in the phasic input to the vestibular system. The present study shows that the head movements of rats were significantly suppressed in the 3G environment. Therefore, we hypothesized that the attenuation of the vestibulo-cardiovascular reflex is induced by the reduced vestibular phasic input caused by the restriction of rear-up behavior. To examine this hypothesis, the pressor responses to linear acceleration were measured in rats reared in a low-roof cage. The linear-acceleration-induced pressor response was significantly suppressed in these rats. The suppressive effect of the low-roof cage was similar to that of 3G. There was no difference in the air-jet-induced pressor response among three groups (rats reared in a usual 1G environment, rats reared in the low-roof cage, and rats reared in the 3G environment), suggesting that the sensitivity of the vestibulo-cardiovascular reflex was selectively suppressed. These results indicate that a reduction in the vestibular phasic input acts to attenuate the vestibulo-cardiovascular reflex.