Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells

Akiyuki Ikedo; Ichiro Hayakawa; Takeo Usui; Sayaka Kazami; Hiroyuki Osada; Hideo Kigoshi

doi:10.1016/j.bmcl.2010.07.111

Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells

Bioorg Med Chem Lett. 2010 Sep 15;20(18):5402-4. doi: 10.1016/j.bmcl.2010.07.111. Epub 2010 Aug 1.

Authors

Akiyuki Ikedo¹, Ichiro Hayakawa, Takeo Usui, Sayaka Kazami, Hiroyuki Osada, Hideo Kigoshi

Affiliation

¹ Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennodai, Tsukuba 305-8571, Japan.

PMID: 20719506
DOI: 10.1016/j.bmcl.2010.07.111

Abstract

Various derivatives of glaziovianin A, an antitumor isoflavone, were synthesized, and the cytotoxicity of each against HeLa S3 cells was investigated. Compared to glaziovianin A, the O7-allyl derivative was found to be more cytotoxic against HeLa S3 cells and a more potent M-phase inhibitor.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemical synthesis
Antineoplastic Agents, Phytogenic / chemistry*
Antineoplastic Agents, Phytogenic / pharmacology*
Cell Cycle / drug effects*
Fabaceae / chemistry
HeLa Cells
Humans
Isoflavones / chemical synthesis
Isoflavones / chemistry*
Isoflavones / pharmacology*
Neoplasms / drug therapy
Structure-Activity Relationship

Substances

Antineoplastic Agents, Phytogenic
Isoflavones
glaziovianin A