Responsive and mitochondria-specific ruthenium(II) complex for dual in vitro applications: two-photon (near-infrared) induced imaging and regioselective cell killing

Hanzhong Ke; Hongda Wang; Wai-Kwok Wong; Nai-Ki Mak; Daniel W J Kwong; Ka-Leung Wong; Hoi-Lam Tam

doi:10.1039/c0cc01848a

Responsive and mitochondria-specific ruthenium(II) complex for dual in vitro applications: two-photon (near-infrared) induced imaging and regioselective cell killing

Chem Commun (Camb). 2010 Sep 28;46(36):6678-80. doi: 10.1039/c0cc01848a. Epub 2010 Aug 18.

Authors

Hanzhong Ke¹, Hongda Wang, Wai-Kwok Wong, Nai-Ki Mak, Daniel W J Kwong, Ka-Leung Wong, Hoi-Lam Tam

Affiliation

¹ Faculty of Material Science & Chemistry Engineering, China University of Geosciences, Wuhan, Hubei 430074, P. R. China.

PMID: 20717606
DOI: 10.1039/c0cc01848a

Abstract

A mitochondria-permeable ruthenium(II) complex has been designed as a responsive probe which may be used to sensitize the formation of singlet oxygen (Phi(Delta) = 0.93) and cause local damage in cellulo when exposed to UV and near-infrared laser excitation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Coordination Complexes / chemistry*
Coordination Complexes / toxicity
Humans
Infrared Rays
Mitochondria / drug effects*
Photons*
Photosensitizing Agents / chemistry
Photosensitizing Agents / toxicity
Ruthenium / chemistry*
Singlet Oxygen / metabolism
Singlet Oxygen / toxicity
Ultraviolet Rays

Substances

Coordination Complexes
Photosensitizing Agents
Singlet Oxygen
Ruthenium