A facile synthesis of 3-substituted 9H-pyrido[3,4-b]indol-1(2H)-one derivatives from 3-substituted beta-carbolines

Guowu Lin; Yue Wang; Qingfa Zhou; Weifang Tang; Jian Wang; Tao Lu

doi:10.3390/molecules15085680

A facile synthesis of 3-substituted 9H-pyrido[3,4-b]indol-1(2H)-one derivatives from 3-substituted beta-carbolines

Molecules. 2010 Aug 17;15(8):5680-91. doi: 10.3390/molecules15085680.

Authors

Guowu Lin¹, Yue Wang, Qingfa Zhou, Weifang Tang, Jian Wang, Tao Lu

Affiliation

¹ College of Basic Science, China Pharmaceutical University, Nanjing 210009, China.

Abstract

A mild and efficient two-step synthesis of 3-substituted beta-carbolinone derivatives from 3-substituted beta-carboline in good yields is described. A possible reaction mechanism for the formation of the skeleton of beta-carbolin-1-one is proposed. The structures of these compounds were established by IR, 1H-NMR, 13C-NMR, mass spectrometry and elemental analysis, as well as X-ray crystallographic analysis of 4-2 and 6-2.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbolines / chemistry*
Chemistry, Organic / methods*
Crystallography, X-Ray
Indoles / chemical synthesis*
Indoles / chemistry*
Molecular Conformation
Time Factors

Substances

Carbolines
Indoles