Abstract
A new benzoquinone-type retro-dihydrochalcone, named evelynin, was isolated from the roots and rhizomes of Tacca chantrieri. The structure was elucidated on the basis of the analysis of spectroscopic data and confirmed by a simple one-step total synthesis. Evelynin exhibited cytotoxicity against four human cancer cell lines, MDA-MB-435 melanoma, MDA-MB-231 breast, PC-3 prostate, and HeLa cervical carcinoma cells, with IC(50) values of 4.1, 3.9, 4.7, and 6.3 μM, respectively.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Benzoquinones / chemistry
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Benzoquinones / isolation & purification*
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Benzoquinones / pharmacology
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Chalcones / chemistry
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Chalcones / isolation & purification*
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Chalcones / pharmacology
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Dioscoreaceae / chemistry*
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Drug Screening Assays, Antitumor
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Female
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HeLa Cells
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Humans
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Inhibitory Concentration 50
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Male
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Rhizome / chemistry
Substances
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Antineoplastic Agents, Phytogenic
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Benzoquinones
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Chalcones
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evelynin
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dihydrochalcone