20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A

ChemMedChem. 2010 Oct 4;5(10):1701-5. doi: 10.1002/cmdc.201000293.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Catalytic Domain
  • Crystallography, X-Ray
  • Peptides, Cyclic / chemistry*
  • Peptides, Cyclic / pharmacology
  • Protease Inhibitors / chemistry*
  • Protease Inhibitors / pharmacology
  • Proteasome Endopeptidase Complex / metabolism
  • Proteasome Inhibitors*

Substances

  • Peptides, Cyclic
  • Protease Inhibitors
  • Proteasome Inhibitors
  • TMC-95A
  • Proteasome Endopeptidase Complex