Abstract
Tetracycline, clindamycin, and other protein synthesis inhibitors at subinhibitory concentrations significantly increased the expression of the pivotal virulence regulator agr and production of the agr-regulated cytolytic phenol-soluble modulins in the community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strain USA300. Our results suggest that such protein synthesis inhibitors may exacerbate the progression of CA-MRSA disease when applied at concentrations that are too low or when treating infections caused by strains resistant to those antibiotics.
Publication types
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Research Support, N.I.H., Intramural
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics*
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Bacterial Toxins / metabolism*
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Cytotoxins / metabolism*
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Methicillin-Resistant Staphylococcus aureus / drug effects*
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Methicillin-Resistant Staphylococcus aureus / metabolism*
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Protein Synthesis Inhibitors / pharmacology*
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Reverse Transcriptase Polymerase Chain Reaction
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Trans-Activators / genetics*
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Virulence
Substances
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Agr protein, Staphylococcus aureus
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Anti-Bacterial Agents
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Bacterial Proteins
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Bacterial Toxins
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Cytotoxins
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Protein Synthesis Inhibitors
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Trans-Activators
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staphylococcal delta toxin