Abstract
Transcription factors play a key role in regulating blood cell fate choice and differentiation. In this review, we examine current knowledge of the function and mode of action of the transcription factors implicated in haematopoiesis in Drosophila. We particularly emphasize regulation by transcription factors and cofactors, such as GATA, FOG and RUNX, whose homologues in mammals also control blood cell formation and we discuss the cross talks between these transcriptional regulators at the different stages of haematopoietic cell fate decision.
Publication types
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Patient Education Handout
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Core Binding Factor alpha Subunits / genetics
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Drosophila / embryology
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Drosophila / genetics
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Drosophila / physiology*
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Drosophila Proteins / genetics
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Drosophila Proteins / physiology*
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Embryo, Nonmammalian / blood supply
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Embryo, Nonmammalian / embryology
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Embryo, Nonmammalian / metabolism
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GATA Transcription Factors / genetics
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Gene Expression Regulation, Developmental
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Hematopoiesis / genetics
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Hematopoiesis / physiology*
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Transcription Factors / genetics
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Transcription Factors / physiology*
Substances
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Core Binding Factor alpha Subunits
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Drosophila Proteins
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GATA Transcription Factors
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Transcription Factors