Abstract
A series of novel sulfanilamide-derived 1,2,3-triazole compounds were synthesized in excellent yields via 1,3-dipolar cycloaddition and confirmed by MS, IR and NMR spectra as well as elemental analyses. All the compounds were screened in vitro for their antibacterial and antifungal activities. Preliminary results indicated that some target compounds exhibited promising antibacterial potency. Especially, 4-amino-N-((1-dodecyl-1H-1,2,3-triazol-4-yl)methyl) benzenesulfonamide, N-((1-(2,4-dichlorobenzyl)- 1H-1,2,3-triazol-4-yl)methyl)-4-aminobenzenesulfonamide and 4-amino-N-((1-(2,4-difluorobenzyl)- 1H-1,2,3-triazol-4-yl)methyl) benzenesulfonamide were found to be the most potent compounds against all the tested strains except for Candida albicans (ATCC76615) and Candida mycoderma.
Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Anti-Infective Agents / chemical synthesis
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Anti-Infective Agents / chemistry*
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Anti-Infective Agents / pharmacology*
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Antifungal Agents / chemical synthesis
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology
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Bacteria / drug effects*
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Bacterial Infections / drug therapy
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Fungi / drug effects*
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Humans
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Magnetic Resonance Spectroscopy
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Mycoses / drug therapy
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Spectrophotometry, Infrared
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Sulfanilamide
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Sulfanilamides / chemical synthesis
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Sulfanilamides / chemistry*
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Sulfanilamides / pharmacology*
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Triazoles / chemical synthesis
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Triazoles / chemistry*
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Triazoles / pharmacology*
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Antifungal Agents
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Sulfanilamides
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Triazoles
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Sulfanilamide