Abstract
Neuropeptide Y (NPY) is a ubiquitous endocrine neuropeptide found in vertebrate and invertebrate. In our present work, two NPY-like exocrine conopeptides (designated as cono-NPYs) were first identified in the venom of cone snails. Both cono-NPYs showed sequence characteristics of invertebrate NPYs, suggesting that some exocrine venom peptides are probably evolved from the preexisting endocrine peptides during the evolution of cone snails.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Behavior, Animal / drug effects
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Behavior, Animal / physiology
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Chromatography, High Pressure Liquid
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Conus Snail / chemistry*
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Conus Snail / genetics
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Dose-Response Relationship, Drug
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Evolution, Molecular
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Hyperkinesis / physiopathology
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Injections, Intraventricular
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Mice
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Molecular Sequence Data
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Molecular Weight
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Mollusk Venoms / chemistry*
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Neuropeptide Y / genetics
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Neuropeptide Y / isolation & purification*
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Neuropeptide Y / pharmacology
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Peptide Fragments / analysis*
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Sequence Homology, Amino Acid
Substances
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Mollusk Venoms
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Neuropeptide Y
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Peptide Fragments