Brønsted acid catalyzed asymmetric aldol reaction: a complementary approach to enamine catalysis

Org Lett. 2010 Aug 20;12(16):3582-5. doi: 10.1021/ol101176j.

Abstract

A syn-enantioselective aldol reaction has been developed using Brønsted acid catalysis based on H(8)-BINOL-derived phosphoric acids. This method affords an efficient synthesis of various beta-hydroxy ketones, some of which could not be synthesized using enamine organocatalysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amanitins / chemistry*
  • Catalysis
  • Combinatorial Chemistry Techniques*
  • Ketones / chemical synthesis*
  • Ketones / chemistry
  • Molecular Structure
  • Phosphoric Acids / chemistry
  • Stereoisomerism

Substances

  • Amanitins
  • Ketones
  • Phosphoric Acids
  • aldoamanitin