As healthcare groups continue to communicate and collaborate at a distance on knowledge exchange activities, Information and Communication Technology (ICT) has come to play an increasingly important role in supporting such interactions. However, to date, the literature on knowledge exchange appears disconnected from that of ICT. Research on the effects of ICT on knowledge exchange activities is needed. The literature review explores the potential impacts ICTs can have on knowledge exchange groups, and especially, the social interaction process. A discussion of how ICTs could impact the social interaction process of knowledge exchange activities is made.