Abstract
A hot-water extract of Aphanothece sacrum, an edible aquacultured blue-green alga, was found to show a remarkable inhibitory effect on the replication of enveloped viruses including herpes simplex virus type 2 (HSV-2) and influenza virus type A (IFV-A, H1N1) in vitro. The main active components were suggested to be sulfated polysaccharides in non-dialyzable portion (ASWPH). ASWPH was found to inhibit the viral adsorption to the receptor of the host cells involved in the replication process of HSV-2 and IFV-A. In addition, while the penetration stage of HSV-2 was also significantly suppressed with ASWPH, no such effect was observed in the replication of IFV-A. These results suggest that ASWPH might be useful in the prevention of infectious diseases caused by HSV-2 as well as IFV-A.
MeSH terms
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Adsorption / drug effects
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Animals
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Chemical Fractionation
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Chlorocebus aethiops
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Complex Mixtures / chemistry
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Complex Mixtures / isolation & purification
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Complex Mixtures / pharmacology*
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Cyanobacteria / chemistry*
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Cyanobacteria / physiology
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Herpesvirus 2, Human / drug effects*
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Herpesvirus 2, Human / metabolism
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Herpesvirus 2, Human / physiology*
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Hot Temperature
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Influenza A virus / drug effects*
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Influenza A virus / metabolism
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Influenza A virus / physiology*
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Polysaccharides, Bacterial / chemistry
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Polysaccharides, Bacterial / isolation & purification
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Polysaccharides, Bacterial / pharmacology
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Sulfuric Acids / chemistry
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Vero Cells
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Virus Replication / drug effects*
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Water / chemistry
Substances
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Complex Mixtures
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Polysaccharides, Bacterial
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Sulfuric Acids
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Water
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sulfuric acid