A rare case of seronegative neurobrucellosis

Ann Saudi Med. 2010 Sep-Oct;30(5):412-4. doi: 10.4103/0256-4947.67084.

Abstract

Neurobrucellosis is one of the complications of brucellosis. We report a rare case of a 17-year-old girl with seronegative neurobrucellosis and depression and diplopia. Results of agglutination tests for Brucella both in serum and CSF were negative. Diagnosis was made only by positive culture of Brucella mellitensis with inoculation of the patient's cerebrospinal fluid in a BACTEC 9050 System. The patient was successfully treated using ceftriaxone, doxycycline and rifampicin therapy for six months.

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents / therapeutic use
  • Brucella melitensis / isolation & purification*
  • Brucellosis / diagnosis*
  • Brucellosis / drug therapy
  • Brucellosis / immunology
  • Ceftriaxone / therapeutic use
  • Cerebrospinal Fluid / microbiology*
  • Depression / etiology
  • Diplopia / etiology
  • Doxycycline / therapeutic use
  • Drug Therapy, Combination
  • Female
  • Humans
  • Nervous System Diseases / diagnosis*
  • Nervous System Diseases / drug therapy
  • Nervous System Diseases / microbiology*
  • Rifampin / therapeutic use

Substances

  • Anti-Bacterial Agents
  • Ceftriaxone
  • Doxycycline
  • Rifampin