Objective: To review the latest research progress of full-thickness tissue engineered skin (FTTES), to thoroughly understand its current state of research and application so as to lay a solid foundation for developing new type FTTES and improving the quality of skin substitutes.
Methods: Domestica and international literature concerning FTTES in recent years was extensively reviewed and comprehensively analyzed.
Results: Some progress of FTTES had made in seed cells, scaffold materials and construction, and some therapeutic efficacy had also been achieved in clinical application. But FTTES grafting successful rate was lower, and it had no complete skin structure and had not reached the requirements of clinical application.
Conclusion: FTTES is an ideal skin substitute and has great development prospects. However, in seed cells, scaffold materials, construction and applications of FTTES, further studied is still needed.