Between 2007-2008 forty two patients neurosurgery department of the KNTB (Regional Hospital of T. Bat'a) Zlin underwent surgery using the bioactive replacement Implaspin. The group of 21 patient of the total of number of 42 patients was operated first time for diagnosis degenerative instability or spondylolisthesis gr I-II. In this group was the follow-up period of 18 months, the mean baseline Oswestry score was 57%. A value of 37% was achieved after 18 months during the evaluation of the clinical status using the Oswestry questionnaire. This result represented a improvement of the condition. No change of the position of the instruments occurred during the X-ray and CT, MRI controls. Therefore, the Implaspin replacement appeared to be a perfect alternative to other lumbar spine replacements combining the osteoconductive properties of the bioactive material with the rigidity of titanium.